Amphetamines are known being metabolized, to some extent, by cytochrome P450 2D6 (CYP2D6) and Screen minor inhibition of CYP2D6 metabolism; probable for a pharmacokinetic interaction exists with coadministration of CYP2D6 inhibitors which may enhance possibility with elevated exposure to amphetamines; in these conditions, consider option non-serotonergic drug or different drug that does not inhibit CYP2D6
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